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KMID : 0362919930110010097
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Journal of the Korean Society for Therapeutic Radiology and Oncology
1993 Volume.11 No. 1 p.97 ~ p.102
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The Results of Radiation Therapy of Limited Stage Small Cell Lung Cancer
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Kim Sung-Hwan
Choi Byung-Ok
Gil Hak-Joon
Yoon Sei-Chul
Bahk Yong-Whee
Shinn Kyung-Sub
Kim Hoon-Kyo
Lee Kyung-Sik
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Abstract
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A retrospective analysis of various characteristics in 32 limited stage small cell lung cancer patients treated at the Department of Therapeutic Radiology in Kangnam St. Mary Hospital, Catholic University Medical College from April 1983 to September 1991, was carried out to identify factors which had prognostic significance for survival from initiation of radiation therapy.
There were 26 men anti 6 women. Median age was 63 years (range: 24-78 years). The follow up duration was 1.5 to 44 months (median: 9 months). External radiation therapy was done with daily 160-180 cGy, 5 fraction/week, total of 1000-6660 cGy (median: 4500 cGy) to the mediastinum by 6 MV linear accelerator.
Of 32 patients, 27 (84.4%) patients were treated with combined modality(chemotherapy plus radiation therapy), and 5(15.6%) patients were treated with radiation therapy only. Complete responders were 12 patients (37.5%), partial responders were 11 (34.4%), and no responders were 9 (28.1%). Karnofsky performance status over 70 (p< 0.04), chemotherapy regimen (CAV, PV, and CAV+PV)(p<0.04), 6 or more cycles of chemotherapy (p<7.077), radiation therapy over 4500 cGy (p<0.03), and radiation therapy responder (CR+PR)(p<0.003) showed a significantly favorable influence on 1 year survival rate. Age(p=0.545), sex(p=0.006), presence of superior versa cava syndrome(p=0.719), prophylactic cranial irradiation (7=0.217), and radiation therapy duration (p=0.491) had no effect on survival.
Radiation induced side effects were transient esophagitis in 11 (34%), general weakness in 9(28%l), gastrointestinal symptoms in terms of nausea, vomiting and indigestion in 5 (15%) and leukopenia in 1(3%).
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KEYWORD
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Radiation Therapy, Limbed Stage Small Cell Lung Cancer
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